Efficacy and moderators of mindfulness-based cognitive therapy (MBCT) in 'Difficult to Treat' depression: protocol for a systematic review and individual participant data meta-analysis of randomised controlled trials.
BMJ Open December 8, 2025 Thorsten Barnhofer, Maria Niemi, Johannes Michalak et al.
Introduction: About 30% of depressed patients suffer from a protracted course in which the disorder continues to cause significant burden despite treatment efforts. While originally developed for relapse prevention, mindfulness-based cognitive therapy (MBCT) has increasingly been investigated in depressed patients with such 'difficult-to-treat' courses. This is a protocol for an individual...
DOI: 10.1136/bmjopen-2025-106350 (opens in new tab)
Full text (opens in new tab)
Depression
Mindfulness
Humans
Treatment outcome
+4