Journal of chemical neuroanatomy
October 2021
Golshad Kowsari, Soraya Mehrabi, Sara Soleimani Asl et al.
MDMA (3,4-Methylenedioxymethamphetamine) is a common recreational drug of abuse which causes neurodegeneration. Nicotine and modafinil provide antioxidant and neuroprotective properties and may be beneficial in the management of MDMA-induced neurotoxicity. The purpose of this study was to characterize how acute and chronic administration of nicotine and/or modafinil exert protective effects...
Metabolic Brain Disease
October 2017
Azam Sajadi, Iraj Amiri, Alireza Gharebaghi et al.
3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy is a derivative of amphetamine that leads to long term potentiation (LTP) disruption in the hippocampal dentate gyrus (DG). Exercise has been accepted as a treatment for the improvement of neurodegenerative disease. Herein, the effects of exercise on the MDMA- induced neurotoxicity were assessed. Male Wistar rats received intraperitoneal...
Journal of Neuroscience Research
May 11, 2017
Alireza Gharebaghi, Iraj Amiri, Iraj Salehi et al.
3,4-methylenedioxymethamphetamine (MDMA) leads to apoptosis in the hippocampus with consequent induction of learning and memory impairment. In this study, we have investigated the effects of treadmill exercise on memory in relation to apoptosis and oxidative stress in the hippocampi of MDMA-treated rats. Male Wistar rats received multiple intraperitoneal (IP) injections of MDMA (10 mg/kg) and...
Medical journal of the Islamic Republic of Iran
2017
Sara Soleimani Asl, Mohamad Bakhtiar Hesam Shariati, Mehdi Medizadeh et al.
Background: 3,4- methylenedioxymethamphetamine (MDMA) is a chemical derivative of amphetamine that can induce learning and memory impairment. Due to the effect of neurotrophins on memory and learning, the impact of MDMA was evaluated on the brain - derived neurotrophic factor (BDNF), neurotrophin- 4 (NT-4), and tropomyosin- related kinase B (Trk- β) expression in the hippocampus. Methods: In...
Metabolic Brain Disease
February 2015
Sara Soleimani Asl, Bita Saifi, Abolhasan Sakhaie et al.
Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) can lead to spatial memory impairments and hippocampal cell death. Numerous evidence indicates that the antioxidant N-acetylcysteine (NAC) exerts protective effects in the brain. The present study evaluates the effects of NAC on MDMA-induced neurotoxicity. We intraperitoneally injected 28 adult male Sprague-Dawley rats (200-250 g) with...
Metabolic Brain Disease
December 2013
Sara Soleimani Asl, Kazem Mousavizadeh, Bagher Pourheydar et al.
Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) leads to spatial memory impairment and hippocampal cell death. In the present study we have examined the protective effects of N-acetyl-L-cysteine (NAC) on MDMA-induced neurotoxicity. A total of 56 male Sprague Dawley rats (200-250 g) received twice daily intraperitoneal (IP) injections of 5, 10 or 20 mg/kg MDMA plus NAC (100 mg/kg). Rectal...