Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

Azam Sajadi; Iraj Amiri; Alireza Gharebaghi; Alireza Komaki; Masoumeh Asadbegi; Siamak Shahidi; Mehdi Mehdizadeh; Sara Soleimani Asl

doi:10.1007/s11011-017-0046-9

Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

Azam Sajadi, Iraj Amiri, Alireza Gharebaghi, Alireza Komaki, Masoumeh Asadbegi, Siamak Shahidi, Mehdi Mehdizadeh, Sara Soleimani Asl

Metabolic Brain Disease October 2017 DOI: 10.1007/s11011-017-0046-9 (opens in new tab)

The journal has published a correction to this paper. Read the correction (opens in new tab)

Read Full Text

Relevant Not relevant

Study at a glance

AI-extracted from the abstract

Characteristics	Controlled animal experiment Peer reviewed
Population	Male Wistar rats
Interventions	MDMA Treadmill exercise
Dose	10 mg/kg
Duration	One month of treadmill exercise
Measures	field excitatory post-synaptic potential (fEPSP) slope, BDNF expression (western blotting)
Topics	MDMA
Keywords	Bdnf Ltp Treadmill exercise
Key findings	MDMA (10 mg/kg) reduced hippocampal fEPSP slope and BDNF expression in rats, while one month of treadmill exercise increased both measures relative to MDMA alone. The authors suggest that synchronous exercise may improve MDMA-induced LTP changes through increased BDNF expression.

Abstract

3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy is a derivative of amphetamine that leads to long term potentiation (LTP) disruption in the hippocampal dentate gyrus (DG). Exercise has been accepted as a treatment for the improvement of neurodegenerative disease. Herein, the effects of exercise on the MDMA- induced neurotoxicity were assessed. Male Wistar rats received intraperitoneal injection of MDMA (10 mg/kg) and exercised for one month on a treadmill (Simultaneously or asynchronously with MDMA). LTP and expression of BDNF were assessed using electrophysiology and western blotting methods, respectively. MDMA attenuated the field excitatory post-synaptic potential (fEPSP) slope in comparison with the control group, whereas treadmill exercise increased this parameter when compared to MDMA group. Furthermore, BDNF expression significantly decreased in MDMA group and treadmill exercise could increase that. In conclusion, results of this study suggest that synchronous exercise is able to improve MDMA-induced LTP changes through increase of BDNF expression in the hippocampus of rats.

Comparable studies

Other preclinical and animal studies on MDMA, most cited first.

Study	Year	Design
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context)	1987	Experimental study
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain	1987	Animal experiment
Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells	2006	In vitro laboratory study
Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat Rats	1998	Experimental study
Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery Squirrel monkeys treated with MDMA	1999	Observational cohort

Citations in the library

Cited by 2

Cites 6

and 1 more in the library