Prenatal Cannabidiol and Δ9-Tetrahydrocannabinol exposure lead to sex-specific disruptions in risk assessment and behavioral switching via divergent rewiring of the adult mPFC
bioRxiv July 2, 2026 Alba Cáceres-Rodríguez, Daniela Iezzi, Olivier Lassalle et al. preprint
Background Prenatal cannabidiol (CBD) consumption is increasing, driven by a perception of safety relative to Δ9-tetrahydrocannabinol (THC). However, the neurodevelopmental risks of gestational CBD remain largely uncharacterized. Methods Using a sex-disaggregated framework, we investigated adult (P100–140) mouse offspring following in utero exposure (GD5-18; 3 mg/kg) to THC or CBD. Behavioral...