Background Prenatal cannabidiol (CBD) consumption is increasing, driven by a perception of safety relative to Δ9-tetrahydrocannabinol (THC). However, the neurodevelopmental risks of gestational CBD remain largely uncharacterized. Methods Using a sex-disaggregated framework, we investigated adult (P100–140) mouse offspring following in utero exposure (GD5-18; 3 mg/kg) to THC or CBD. Behavioral...
Defective brain extracellular matrix (ECM) is a factor of vulnerability in various psychiatric diseases such as schizophrenia, depression and autism. The glycoprotein reelin is an essential building block of the brain ECM that modulates neuronal development and participates to the functions of adult central synapses. The reelin gene (RELN) is a strong candidate in psychiatric diseases of early...
Olivier J. J. Manzoni, Alba Cáceres-Rodríguez, Daniela Iezzi et al.
preprint
Abstract Prenatal cannabidiol (CBD) consumption is rapidly increasing, driven by a perception of safety relative to delta9-tetrahydrocannabinol (THC). However, the long-term neurodevelopmental risks of gestational CBD remain largely uncharacterized. Using a sex-disaggregated framework, we investigated adult (P100–140) mouse offspring following in utero exposure (GD5–18; 3 mg/kg) to THC or CBD....