The genus Acacia , comprising approximately 1000 native Australian species, represents a major contributor to the biodiversity of the continent. Some species of Acacia are known to contain bioactive alkaloids, including the popular psychedelic N,N-dimethyltryptamine (DMT). However, systematic phytochemical characterisation across different species of Acacia and tissue types remains limited....
PsychopharmacologyDecember 2025Danielle McCartney, Jordan Levoux, Rebecca Gordon et al.
RATIONALE: Δ9-tetrahydrocannabinol (THC), the principal intoxicant in cannabis, is a highly lipophilic substance that is readily stored in fat. Preclinical research suggests that fat-stored THC can be released into circulation under lipolytic conditions, such as stress. However, compelling evidence of this phenomenon is lacking in humans. OBJECTIVES: Here, we investigated the effects of acute...
NEJM evidenceSeptember 2023Philip E Mosley, Lachlan Webb, Anastasia Suraev et al.
BACKGROUND: Tourette syndrome is characterized by chronic motor and vocal tics. There is preliminary evidence of benefit from cannabis products containing Δ9-tetrahydrocannabinol (THC) and that coadministration of cannabidiol (CBD) improves the side-effect profile and safety. METHODS: In this double-blind, crossover trial, participants with severe Tourette syndrome were randomly assigned to a...