Does acute stress induced via cold water immersion increase blood THC concentrations in regular cannabis users?
Psychopharmacology December 2025 Danielle McCartney, Jordan Levoux, Rebecca Gordon et al.
RATIONALE: Δ9-tetrahydrocannabinol (THC), the principal intoxicant in cannabis, is a highly lipophilic substance that is readily stored in fat. Preclinical research suggests that fat-stored THC can be released into circulation under lipolytic conditions, such as stress. However, compelling evidence of this phenomenon is lacking in humans. OBJECTIVES: Here, we investigated the effects of acute...
DOI: 10.1007/s00213-025-06833-8 (opens in new tab)
Full text (opens in new tab)
Biomarkers
Cannabinoid
Cognition
Drug testing
+5