Contemporarybiocomputingoftenapproachesbrainorganoidsasallopoieticsub-strates for logical processing, neglecting the existential imperatives that drive biolog-ical cognition. This paper proposes a fundamental paradigm shift from AllopoieticComputing toward Autopoietic Computing, grounding the emergence of sentiencein the thermodynamic necessity of survival. By integrating the Mortal...