We determined MDA's effects on: (a) conditioning of the rabbit's jaw movement response (JMR) (Experiment 1); and (b) nonassociative JMRs and unconditioned JMRs (Experiment 2). Rabbits were administered 3,4-methylenedioxyamphetamine (MDA; 0, 2, or 4 mg/kg) into the marginal ear vein 20-30 min prior to each of 10 daily sessions. Experiment 1 involved 30 daily training trials of 15 tone- and 15...
The present investigations sought to determine the effects of 3,4-methylenedioxyamphetamine (MDA) on: 1) differential conditioning of the rabbit's nictitating membrane response to the serial compounds A-X-US (tone-light-reinforced compound) and B-X (white noise-light-unreinforced compound) by examining differential responding to A and B and their conditional control over responding to X within...
In Experiment 1, classical conditioning of the rabbit's nictitating membrane response (NMR) was accomplished by pairing tone and light conditioned stimuli (CSs) with a shock unconditioned stimulus (UCS). MDA impaired the acquisition of conditioned responses (CR) to a tone-CS, while significantly enhancing CR acquisition to a light-CS. Experiment 2, employing explicitly unpaired CS, UCS...