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Effects of delta 9-tetrahydrocannabinol and social context on marijuana self-administration by humans.

T H Kelly, Richard W Foltin, M T Mayr, Marian W Fischman

Pharmacology, Biochemistry, and Behavior November 1994 DOI: 10.1016/0091-3057(94)90099-x (opens in new tab)

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AI-extracted from the abstract
Characteristics Residential within-subject laboratory study with counterbalanced order and an order reversal Peer reviewed
Sample size 6
Population Adult male marijuana smokers
Intervention Marijuana cigarettes (0.0% or 2.3% delta 9-THC)
Dose 0.0% or 2.3% delta 9-THC; up to eight marijuana cigarettes per day
Duration 12-day residential study
Measures visual-analog scales for High, Liking, Potency, and Drug, number of marijuana cigarettes smoked
Topics Cannabis
Key points Marijuana self-administration followed stable individual daily patterns: three of six men smoked more during the social-access period regardless of when it occurred, and three smoked more during the first period regardless of whether it was work or social access. The number of cigarettes smoked was unrelated to THC content, and subjective ratings of High, Liking, Potency, and Drug, though higher on active-marijuana days, did not predict self-administration.

Abstract

The effects of time of day and social context on daily patterns of marijuana self-administration were examined in two groups of three adult male marijuana smokers during a 12-day residential study. Days were divided into 6.5-h work and social-access periods. Order of occurrence (i.e., work before social access or social access before work) was counterbalanced between groups and reversed for both groups on day 8. Up to eight marijuana cigarettes (0.0% or 2.3% delta 9-THC) could be smoked each day. Stable patterns of marijuana smoking were observed across days for each subject. Three subjects smoked more marijuana during the social-access period, regardless of when it occurred. The other three smoked more marijuana during the first period, regardless of whether it was a work or social-access period. The number of marijuana cigarettes smoked was unrelated to THC content. In contrast, subjective reports of "High," "Liking," "Potency" and "Drug" on visual-analog scales were increased on active marijuana days. Subjective reports of drug effects were not predictive of drug self-administration.

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