European Journal of Pharmacology
May 1, 2026
Esteban Merino, A. Cervera-Ferri, Enrique Lanuza et al.
Ketamine exerts rapid, long-lasting antidepressant effects after a single administration and thus overcomes the limitations of classic drugs, but also induces psychomimetic effects. It is, therefore, essential to delve deeper into its mechanisms of action to optimize its use as an antidepressant. With this aim, we examined, in male mice, the temporal evolution of the antidepressant-like and...
Brain Structure and Function
August 7, 2021
Raquel Pascual-Antón, Arantxa Blasco‐Serra, Emma Muñoz‐Moreno et al.
6 citations
Ketamine has rapid and robust antidepressant effects. However, unwanted psychotomimetic effects limit its widespread use. Hence, several studies examined whether GluN2B-subunit selective NMDA antagonists would exhibit a better therapeutic profile. Although preclinical work has revealed some of the mechanisms of action of ketamine at cellular and molecular levels, the impact on brain circuitry...
Neuropharmacology
April 1, 2016
R. Linge, Laura Jiménez-Sánchez, L. Campa et al.
Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD following acute and chronic administration in the olfactory bulbectomy mouse...
Schizophrenia Bulletin
September 28, 2011
Albert Adell, Laura Jiménez-Sánchez, Xavier López-Gil et al.
134 citations
Several genetic, neurodevelopmental, and pharmacological animal models of schizophrenia have been established. This short review examines the validity of one of the most used pharmacological model of the illness, ie, the acute administration of N-methyl-D-aspartate (NMDA) receptor antagonists in rodents. In some cases, data on chronic or prenatal NMDA receptor antagonist exposure have been...
The International Journal of Neuropsychopharmacology
July 7, 2011
Xavier López-Gil, Laura Jiménez-Sánchez, Tamara Romón et al.
35 citations
Previous studies have shown that systemic, but not unilateral intra-prefrontal cortex administration of non-competitive NMDA antagonists, increased prefrontal activity, the cortical efflux of serotonin, and induced stereotypies. In this work we used in-vivo microdialysis and immunohistochemistry to test the hypothesis as to whether MK-801 and ketamine need to act on both prefrontal cortices to...