Distinguishing psychomimetic from antidepressant-like effects in mice using molecular and electrophysiological biomarkers.
European Journal of Pharmacology May 1, 2026 Esteban Merino, A. Cervera-Ferri, Enrique Lanuza et al.
Ketamine exerts rapid, long-lasting antidepressant effects after a single administration and thus overcomes the limitations of classic drugs, but also induces psychomimetic effects. It is, therefore, essential to delve deeper into its mechanisms of action to optimize its use as an antidepressant. With this aim, we examined, in male mice, the temporal evolution of the antidepressant-like and...