Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice
International Journal of Molecular Sciences August 26, 2021 R. Estrada-Reyes, Daniel Quero-Chávez, C. Trueta et al.
A combination of a non-effective dose of ketamine and melatonin (KET/MEL) increased neurogenesis and produced antidepressant-like effects in mice without altering locomotor activity, after both single and triple administration protocols. The authors strongly suggest that this combination could promote neurogenesis, revert neuronal atrophy, and induce antidepressant-like effects, potentially offering a treatment that avoids the psychomimetic side effects of ketamine alone.