Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice
International Journal of Molecular Sciences August 26, 2021 Rosa Estrada-Reyes, Daniel Quero-Chávez, Citlali Trueta et al.
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks to be effective with forty percent of patients being resistant to treatment, making it necessary to search for new antidepressant treatments. Ketamine, a phencyclidine hydrochloride derivative, given intravenously,...