S. Choi

2 papers in the library · publishing 2019-2021

Papers

2-((2-(4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl)ethyl)amino)methyl)phenol (25C-NBOH) induce adverse effects on the cardiovascular system.

Toxicology Letters November 1, 2021 K. S. Yoon, Hye Jin Cha, S. Choi et al.

Two new psychoactive substances, 25I-NBOH and 25C-NBOH, abused as recreational hallucinogens, were evaluated for cardiotoxicity. In cell and animal tests, both compounds decreased viability of rat heart cells and prolonged QT and RR intervals in rat electrocardiography, indicating potential heart rhythm disturbances. 25I-NBOH reduced PAK1 protein expression in heart cells and inhibited potassium channels in a hERG assay, while 25C-NBOH did not affect PAK1 expression. Neither substance altered the pumping function or heart rate of isolated rat hearts. The findings suggest both substances may pose cardiovascular risks, with further research needed on the role of PAK1.

DOI: 10.1016/j.toxlet.2021.11.016 Medicine Chemistry

A Case Study of Imagery Rehearsal Therapy in a Nightmare Disorder Patient with Posttraumatic Stress Disorder

Journal of Sleep Medicine June 30, 2019 Soyeong Park, S. Choi, E. Joo et al.

A brief cognitive behavioral therapy for insomnia (CBT-I) delivered via a mobile app significantly improved sleep quality and reduced insomnia severity in adults with chronic insomnia. Participants using the app showed moderate to large improvements in sleep efficiency, total sleep time, and time to fall asleep compared to a control group. The app-based treatment also reduced maladaptive sleep-related beliefs. These gains were maintained at a one-month follow-up, suggesting that digital CBT-I can be an effective and accessible treatment option for chronic insomnia.

DOI: 10.13078/jsm.19028 Full text Medicine Psychology