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Hui Yan

6 papers in the library · 38 citations · publishing 2020-2025

Papers

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Metabolism study of two phenethylamine - derived new psychoactive substances using in silico, in vivo, and in vitro approaches.

Archives of Toxicology March 10, 2025 Yiling Tang, Linhao Xu, Zhenshuo Guo et al. 1 citation

New psychoactive substances (NPS) are substances that are not controlled by international drug control conventions but are abused and pose a threat to public health. Proscaline and methallylescaline are two phenylethylamines with psychoactive and stimulant effects and are also derivatives of the classic hallucinogen mescaline. However, limited toxicity information on proscaline and...

Qualitative confirmation of 30 phencyclidine analogs in human blood and urine using GC-HRMS and a self-built library search.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences February 1, 2025 Zixuan Song, Zhenshuo Guo, Yiling Tang et al. 1 citation

Phencyclidine, a dissociative anesthetic with hallucinogenic effects, is commonly abused as a recreational drug. Phencyclidine analogs are compounds produced by substitutions of the phenyl and piperidine rings of phencyclidine. Illegal use of phencyclidine and its analogs has symptoms such as addiction, confusion, and increased tendencies toward violence. In this study, a novel high-throughput...

In vitro and in vivo metabolic study of three new psychoactive β-keto-arylcyclohexylamines.

Journal of Analytical Toxicology May 20, 2024 Linhao Xu, Hui Yan, Yiling Tang et al. 3 citations

Since the 2000s, an increasing number of new psychoactive substances have appeared on the illicit drug market. β-Keto-arylcyclohexylamine compounds play important pharmacological roles in anesthesia; however, because these new psychoactive substances have rapidly increasing illicit recreational use, the lack of detailed toxicity data are of particular concern. Therefore, analysis of their...

Sensitive quantitative analysis of psilocin and psilocybin in hair samples from suspected users and their distribution in seized hallucinogenic mushrooms

Forensic Toxicology February 2, 2021 Liying Zhou, Ping Xiang, Di Wen et al. 13 citations

Abstract Purpose In this study, we developed a very sensitive method for quantitative analysis of psilocin and psilocybin in hair samples of magic mushroom consumers. Methods The analyses were performed with pretreatments of samples, followed by ultra-high pressure liquid chromatography (LC) connected to a Q-Trap type tandem mass spectrometry (MS/MS). For LC, mobile phase (A) consisted of 0.1%...

Development of an LC-MS/MS method for determining 5-MeO-DIPT in dried urine spots and application to forensic cases.

Journal of Forensic and Legal Medicine May 1, 2020 Xiuying Yan, Shuai Yuan, Zhiguo Yu et al.

The dried urine spots (DUSs) technique is increasing continuously as an easy sampling method for monitoring substance abuse due to its advantages of stability and convenience regarding transport and storage. 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a new type of tryptamine hallucinogen, the use of which has been banned in many countries. And according to the previous research,...

Determination of 5-MeO-DIPT in Human Urine Using Gas Chromatography Coupled with High-Resolution Orbitrap Mass Spectrometry

Journal of Analytical Toxicology January 29, 2020 Xiuying Yan, Ping Xiang, Yunli Zhao et al. 20 citations

5-Methoxy-N,N-Diisopropyltryptamine (5-MeO-DIPT) is a designer hallucinogen derived from tryptamine and its use has been banned by many countries. In this study, a qualitative and quantitative method was developed for determining 5-MeO-DIPT in urine by gas chromatography high-resolution mass spectrometry. 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT) and 5-methoxy-N-isopropyltryptamine...