From default-mode to action-mode: biphasic network reconfiguration with meditation in schizophrenia
medRxiv November 20, 2025 Qing Wang, Lizhao Du, Jialing Sheng et al. preprint
Whether and how meditation benefits severe psychosis over clinically meaningful timescales remains unclear. We embedded longitudinal neuroimaging in an eight-month, parallel group randomized clinical trial (ChiCTR1800014913) of male inpatients (n=64) with schizophrenia receiving daily clinician-guided meditation plus rehabilitation versus rehabilitation alone. Meditation improved the symptoms...