Lizhao Du

2 papers in the library · publishing 2024-2025

Papers

From default-mode to action-mode: biphasic network reconfiguration with meditation in schizophrenia

medRxiv November 20, 2025 Qing Wang, Lizhao Du, Jialing Sheng et al. preprint

An eight-month randomized clinical trial of male inpatients with schizophrenia found that daily clinician-guided meditation plus rehabilitation improved symptoms by 11.8% at 3 months and 20.8% at 8 months, and improved cognition by 7.6% at 3 months, which then plateaued. Early cognition improvement predicted but did not mediate later symptom relief. Brain imaging revealed a biphasic pattern: baseline default-mode-cerebellar complexity predicted 3-month benefit, while 3-month action-mode/sensorimotor-executive complexity predicted 8-month gains. These findings support a biphasic network reconfiguration model for meditation in schizophrenia and suggest phase-specific markers for personalized treatment.

DOI: 10.1101/2025.11.20.25340575 Full text Medicine Psychology

Enhancing specialization of attention-related EEG power and phase synchronism brain patterns by meditation.

Cerebral Cortex July 1, 2024 Yupeng Han, Lizhao Du, Qiyun Huang et al.

Long-term meditation experience produces detectable neurophysiological changes in brain activity, possibly enhancing functional segregation and specialization. Electroencephalogram data from 20 long-term meditators and 20 nonmeditators during cognitive tasks and a relaxed state showed that meditators had higher classification accuracy and calculation efficiency. During a calculation task, both the power and global phase synchronism of gamma response decreased in meditators compared to their relaxation state, while no such change occurred in nonmeditators. These findings suggest meditation improves brain flexibility through neural plastic mechanisms.

DOI: 10.1093/cercor/bhae288 Medicine Psychology