Disrupted Emergent Properties of the Brain in Schizophrenia: Insight From Integrated Information Decomposition of Resting State fMRI.
Brain and Behavior April 1, 2026 Livio Tarchi, Lorenzo Lasagni, Leonardo Ubaldi et al.
Integrated information decomposition of resting-state fMRI data from 72 people with schizophrenia and 74 healthy controls revealed that redundancy in brain connectivity was positively correlated with IQ across both groups. Within patients, information metrics were positively correlated with stereotyped thinking, preoccupation, and positive symptoms. Diagnostic accuracy reached 84.93% balanced accuracy (area under the curve = 92.30%) using redundancy. These preliminary findings suggest that information metrics may offer clinically relevant, interpretable biomarkers for schizophrenia.