Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network.
Psychopharmacology November 1, 2025 Marta De Felice, Hanna J Szkudlarek, Matthew J Jones et al.
RATIONALE: Chronic cannabis during adolescence is associated with long-lasting pathological outcomes, and these effects can be remarkably different between the sexes. Preclinical studies in rodents demonstrated that sustained exposure to Δ9-tetrahydrocannabinol (THC), induces sex-specific pathophysiological outcomes. Thus, while males exhibit higher vulnerability to schizophrenia-like...
DOI: 10.1007/s00213-025-06817-8 (opens in new tab)
Full text (opens in new tab)
Anxiety
THC
Adolescence
Females
+5