THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways.
Progress in neuro-psychopharmacology & biological psychiatry January 10, 2021 Hanna J Szkudlarek, Mar Rodríguez-ruiz, Roger Hudson et al.
Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs. CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays antipsychotic and anxiolytic properties. A key brain region responsible for regulation of cognition and affect, the medial prefrontal cortex (PFC), is strongly modulated by cannabinoids, suggesting that these dissociable...