Psychopharmacology
December 12, 2025
Ilenia Salsano, Giorgia Picci, Nathan M Petro et al.
Cannabis is one of the most widely used psychoactive drugs in the United States, yet its long-term effects on brain function remain poorly understood. Prior resting-state functional connectivity (rsFC) studies have yielded inconsistent findings, likely due to variability in cannabis use thresholds, a predominant focus on younger populations, and region-of-interest (ROI)-based approaches limited...
Addiction Biology
February 1, 2025
Kellen M McDonald, Mikki Schantell, Jason A John et al.
Despite its widespread use and popularity, cannabis is known to impact higher order cognitive processes such as attention and executive function. However, far less is known about the impact of chronic cannabis use on cognitive flexibility, a component of executive function, and this is especially true for the underlying functional connectivity dynamics. To address this, we enrolled 25 chronic...
Neurobiology of Disease
February 1, 2025
Peihan J Huang, Jake J Son, Yasra Arif et al.
The legalization of recreational cannabis use has expanded the availability of this psychoactive substance in the United States. Research has shown that chronic cannabis use is associated with altered working memory function, however, the brain areas and neural dynamics underlying these affects remain poorly understood. In this study, we leveraged magnetoencephalography (MEG) to investigate...
Brain Communications
2025
Mikki Schantell, Mia C Lulli, Kellen M McDonald et al.
The main psychoactive component in cannabis-Δ9-tetrahydrocannabinol-is known to have anti-inflammatory properties and to alter gamma oscillations, pointing to its potential as a therapeutic agent for people with HIV (PWH). However, it remains unknown how cannabis use among PWH interacts with the neural circuitry underlying inhibitory processing. Herein, using a cross-sectional study design, we...
Journal of psychopharmacology (Oxford, England)
November 1, 2024
Lauren K Webert, Mikki Schantell, Jason A John et al.
People who regularly use cannabis exhibit altered brain dynamics during cognitive control tasks, though the impact of regular cannabis use on the neural dynamics serving motor control remains less understood. We sought to investigate how regular cannabis use modulates the neural dynamics serving motor control. Thirty-four people who regularly use cannabis (cannabis+) and 33 nonusers (cannabis-)...
Human Brain Mapping
August 1, 2024
Mikki Schantell, Jason A John, Anna T Coutant et al.
Regular cannabis use is associated with cortex-wide changes in spontaneous and oscillatory activity, although the functional significance of such changes remains unclear. We hypothesized that regular cannabis use would suppress spontaneous gamma activity in regions serving cognitive control and scale with task performance. Participants (34 cannabis users, 33 nonusers) underwent an interview...
Journal of psychopharmacology (Oxford, England)
August 1, 2024
Camilo A Castelblanco, Seth D Springer, Mikki Schantell et al.
Cannabis is the most widely used psychoactive drug in the United States. While multiple studies have associated acute cannabis consumption with alterations in cognitive function (e.g., visual and spatial attention), far less is known regarding the effects of chronic consumption on the neural dynamics supporting these cognitive functions. We used magnetoencephalography (MEG) and an established...
Journal of psychopharmacology (Oxford, England)
May 2024
Kellen M McDonald, Mikki Schantell, Lucy K Horne et al.
Regular cannabis is known to impact higher-order cognitive processes such as attention, but far less is known regarding cognitive flexibility, a component of executive function. Moreover, whether such changes are related to aberrations in the neural oscillatory dynamics serving flexibility remains poorly understood. Quantify the neural oscillatory dynamics serving cognitive flexibility by...