Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives
ACS Chemical Neuroscience June 6, 2025 Anna Czopek, Jakub Jończyk, Monika Fryc et al. 9 citations
Millions worldwide suffer from chronic pain, a complex condition often accompanied by depression and anxiety, highlighting the urgent need for innovative treatments. Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT), primarily act on serotonin 5-HT2A receptors and have emerged as potential modulators of pain perception and mood...