Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use
International Journal of Neuropsychopharmacology April 1, 2026 Mary M Torregrossa, Tamara Racic, S. Baglot et al.
Abstract Background Most substance users are polysubstance users; however, little is known about how the combined use of different drugs affects the course of substance use disorder or effectiveness of treatment. Notably, co-use of cannabis and nicotine is very common, and we previously demonstrated that nicotine enhances the self-administration of a synthetic cannabinoid receptor agonist and...