Communications Biology
April 20, 2022
Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas et al.
The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness (DOC). Here, we sought to identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead to common reconfigurations of neural activity. We developed and...
Proceedings of the National Academy of Sciences of the United States of America
July 23, 2021
Lennart R.b. Spindler, Andrea I. Luppi, Ram Adapa et al.
Significance Understanding the neural bases of consciousness is of basic scientific and clinical importance. Human neuroimaging has established that a network of interconnected brain regions known as the default mode network disintegrates in anesthesia and after brain damage that causes disorders of consciousness. However, the neurochemical underpinnings of this network change remain largely...
Scientific Reports
February 25, 2020
Deniz Vatansever, Manuel S. Schröter, Ram Adapa et al.
Patterns of functional interactions across distributed brain regions are suggested to provide a scaffold for the conscious processing of information, with marked topological alterations observed in loss of consciousness. However, establishing a firm link between macro-scale brain network organisation and conscious cognition requires direct investigations into neuropsychologically-relevant...
PLoS One
February 13, 2020
Thomas F. Varley, Michael M. Craig, Ram Adapa et al.
Recent evidence suggests that the quantity and quality of conscious experience may be a function of the complexity of activity in the brain and that consciousness emerges in a critical zone between low and high-entropy states. We propose fractal shapes as a measure of proximity to this critical point, as fractal dimension encodes information about complexity beyond simple entropy or randomness,...
Nature Communications
October 10, 2019
Andrea I. Luppi, Michael M. Craig, Ioannis Pappas et al.
Prominent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the brain. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and patients with disorders of consciousness, in order to...
Human Brain Mapping
2017
Deniz Vatansever, Anne E. Manktelow, Barbara J. Sahakian et al.
AbstractInitially identified during no‐task, baseline conditions, it has now been suggested that the default mode network (DMN) engages during a variety of working memory paradigms through its flexible interactions with other large‐scale brain networks. Nevertheless, its contribution to whole‐brain connectivity dynamics across increasing working memory load has not been explicitly assessed. The...