Phencyclidine Model of Frontal Cortical Dysfunction in Nonhuman Primates
The Neuroscientist August 1, 2000 J. David Jentsch, Jane R. Taylor, Robert H. Roth
Long-term intake of noncompetitive N-methyl-D-aspartate (NMDA)/glutamate receptor antagonists, such as phencyclidine (PCP), can simulate schizophrenia-like symptomatology in human subjects and can produce aberrant behavior in animals. The behavioral changes produced by PCP in animals have been suggested to model certain primary symptoms of idiopathic psychotic disorders, and the neurobiological...