The role of the hippocampo-prefrontal cortex system in phencyclidine-induced psychosis: a model for schizophrenia.
Journal of physiology, Paris December 1, 2013 Eiichi Jodo
Phencyclidine (PCP) is a psychotomimetic drug that induces schizophrenia-like symptoms in healthy individuals and exacerbates pre-existing symptoms in patients with schizophrenia. PCP also induces behavioral and cognitive abnormalities in non-human animals, and PCP-treated animals are considered a reliable pharmacological model of schizophrenia. However, the exact neural mechanisms by which PCP...