Pharmacology, biochemistry, and behavior
December 1, 1993
Cathleen S. Dohrn, J L Lichtor, Dennis W. Coalson et al.
The reinforcing, subjective, and psychomotor effects of 30 min of inhalation of 20% nitrous oxide were determined in 12 healthy volunteers using a choice paradigm with 100% oxygen as placebo. Nitrous oxide was chosen on only 22% of choice occasions, indicating that, in general, this concentration did not function as a reinforcer. Nitrous oxide produced changes in mood, but had no effect on...
Human Psychopharmacology: Clinical and Experimental
March 1, 1993
Cathleen S. Dohrn, J. Lance Lichtor, Dennis W. Coalson et al.
AbstractNitrous oxide, commonly used in medical settings for its anxiolytic, analgesic, and anesthetic effects, is also used recreationally. One method of using this agent recreationally is to inhale a pure bolus of nitrous oxide (N2 O) one or more times in succession. The effects of such an inhalation mode (i.e. brief inhalation of higher concentrations of N2 O) have not been adequately...
Drug and Alcohol Dependence
February 1, 1993
Cathleen S. Dohrn, J L Lichtor, Dennis W. Coalson et al.
The subjective, psychomotor and reinforcing effects of nitrous oxide at subanesthetic doses (30% and 40% in oxygen) were determined in normal healthy volunteers using a choice paradigm. Thirty percent nitrous oxide was chosen no more often than oxygen (41.6% choice rate), indicating that, for most of the subjects tested, extended inhalation of this nitrous oxide concentration was no more...
Behavioural Pharmacology
February 1, 1992
Cathleen S. Dohrn, J.L. Lichtor, R.S. Finn et al.
The effects of nitrous oxide at subanesthetic doses (0%, 10%, 20%, and 40% in oxygen) on mood and psychomotor performance were determined in a group of 12 healthy volunteers (six males and six females). A randomized, placebo-controlled, double-blinded, crossover trial of five experimental sessions was used. Effects were measured before, during and after a 30-min inhalation period of the agent,...