Frontiers in Psychology
2025
Emma R. Huels, Lily Carter, Gang Xu et al.
Previous studies have demonstrated acute changes in brain activity that occur during shamanic journeying-an ancient spiritual practice used for physical, psychological, and spiritual healing. However, the effect of shamanic journeying on other physiological measures, such as heart rate variability, remains unknown. We investigated changes in heart rate variability (HRV) during sessions of...
Scientific Reports
January 6, 2023
Nicolas G. Glynos, Lily Carter, Soo Jung Lee et al.
17 citations
Indolethylamine N-methyltransferase (INMT) is a transmethylation enzyme that utilizes the methyl donor S-adenosyl-L-methionine to transfer methyl groups to amino groups of small molecule acceptor compounds. INMT is best known for its role in the biosynthesis of N,N-Dimethyltryptamine (DMT), a psychedelic compound found in mammalian brain and other tissues. In mammals, biosynthesis of DMT is...
Scientific Reports
June 27, 2019
Jon G Dean, Tiecheng Liu, Sean Huff et al.
111 citations
N,N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). Whether DMT is biosynthesized in the mammalian brain is unknown. We investigated brain expression of INMT transcript in rats and humans, co-expression of INMT and AADC mRNA in rat brain and...
Biomedical chromatography : BMC
December 1, 2013
Steven A. Barker, Jimo Borjigin, Izabela Lomnicka et al.
73 citations
We report a qualitative liquid chromatography-tandem mass spectrometry (LC/MS/MS) method for the simultaneous analysis of the three known N,N-dimethyltryptamine endogenous hallucinogens, their precursors and metabolites, as well as melatonin and its metabolic precursors. The method was characterized using artificial cerebrospinal fluid (aCSF) as the matrix and was subsequently applied to the...
Proceedings of the National Academy of Sciences of the United States of America
August 27, 2013
Jimo Borjigin, UnCheol Lee, Tiecheng Liu et al.
The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of the brain immediately following cardiac arrest has not been systematically investigated. In this study, we performed continuous electroencephalography in rats undergoing experimental cardiac arrest and analyzed changes in power density, coherence, directed connectivity, and cross-frequency...