BACKGROUND AND HYPOTHESIS: Up to 43% of people with schizophrenia have a lifetime cannabis use disorder (CUD). Tetrahydrocannabinol (THC) has been shown to exacerbate psychosis in a dose-dependent manner, but little research has assessed its effects on schizophrenia and co-occurring CUD (SCZ-CUD). In this double-dummy, placebo-controlled trial (total n = 130), we hypothesized that a modest dose...
The powerful psychoactive features of N,N-dimethyltryptamine (DMT) have sparked the imagination of many research disciplines for several decades. One of the key chemical features associated with compound identity is the determination of melting points. The descriptions of both melting points and morphology associated with DMT free base have long been a source of interest and discussion,...