Correlation of psychotomimetic activity of phenethylamines and amphetamines with 1-octanol-water partition coefficients
Journal of Medicinal Chemistry February 1, 1975 Charles F. Barfknecht, David E. Nichols, William J. Dunn 42 citations
In an attempt to relate the hallucinogenic potencies in man of some biologically important amphetamines and phenethylamines, the 1-octanol-water partition coefficients for 11 amphetamines were determined. Using these values and published Hansch pi constants, the log P for 17 additional amines was estimated. It was found that lipophilicity, as measured by the log of the partition coefficient,...