Neuroimage
May 15, 2011
Christophe Phillips, Marie-Aurélie Bruno, Pierre Maquet et al.
The vegetative state is a devastating condition where patients awaken from their coma (i.e., open their eyes) but fail to show any behavioural sign of conscious awareness. Locked-in syndrome patients also awaken from their coma and are unable to show any motor response to command (except for small eye movements or blinks) but recover full conscious awareness of self and environment. Bedside...
Progress in Brain Research
2011
Athena Demertzi, Andrea Soddu, M-E Faymonville et al.
Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-frequency spontaneous activity in a default mode network (encompassing medial brain areas and linked to self-related processes) and an anticorrelated "extrinsic" system (encompassing lateral frontoparietal areas and modulated via external sensory stimulation). In order to better determine the...
Anesthesiology
September 30, 2010
Pierre Boveroux, Audrey Vanhaudenhuyse, Marie-Aurélie Bruno et al.
645 citations
BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during...
Journal of Cognitive Neuroscience
June 1, 2010
Audrey Vanhaudenhuyse, Athena Demertzi, Manuel Schabus et al.
460 citations
Evidence from functional neuroimaging studies on resting state suggests that there are two distinct anticorrelated cortical systems that mediate conscious awareness: an "extrinsic" system that encompasses lateral fronto-parietal areas and has been linked with processes of external input (external awareness), and an "intrinsic" system which encompasses mainly medial brain areas and has been...
Human Brain Mapping
May 8, 2008
Melanie Boly, Christophe Phillips, Evelyne Balteau et al.
73 citations
The origin of within-subject variability in perceptual experiments is poorly understood. We here review evidence that baseline brain activity in the areas involved in sensory perception predict subsequent variations in sensory awareness. We place these findings in light of recent findings on the architecture of spontaneous BOLD fluctuations in the awake human brain, and discuss the possible...