Marco Loh

A Dynamical Systems Hypothesis of Schizophrenia

PLoS Computational Biology November 7, 2007 Marco Loh, Edmund T Rolls, Gustavo Deco 172 citations

We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the constant statistical fluctuations caused by the stochastic spiking of neurons. In integrate-and-fire network simulations, a decrease in the NMDA...