Lilian Weber

2 papers in the library · 82 citations · publishing 2020-2023

Papers

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Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection.

British Journal of Anaesthesia October 2023 Jordan J Wehrman, Cameron P Casey, Sean Tanabe et al.

Sensory disconnection is a key feature of sleep and anaesthesia. We have proposed that predictive coding offers a framework for understanding the mechanisms of disconnection. Low doses of ketamine that do not induce disconnection should thus diminish predictive coding, but not abolish it. Ketamine was administered to 14 participants up to a blood concentration of 0.3 μg ml-1 Participants were...

DOI: 10.1016/j.bja.2023.06.044 Full text Ketamine Nmda Electroencephalography Hierarchical gaussian filter +3

Ketamine Affects Prediction Errors about Statistical Regularities: A Computational Single-Trial Analysis of the Mismatch Negativity

Journal of Neuroscience June 19, 2020 Lilian Weber, Andreea O. Diaconescu, Christoph Mathys et al. 82 citations

The auditory mismatch negativity (MMN) is significantly reduced in schizophrenia. Notably, a similar MMN reduction can be achieved with NMDA receptor (NMDAR) antagonists. Both phenomena have been interpreted as reflecting an impairment of predictive coding or, more generally, the "Bayesian brain" notion that the brain continuously updates a hierarchical model to infer the causes of its sensory...

DOI: 10.1523/jneurosci.3069-19.2020 Full text Ketamine Mismatch negativity Negativity effect Cognitive psychology +1