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Robert A Pearce

2 papers in the library · 5 citations · publishing 2024

Papers

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Divergent Effects of Ketamine and the Serotoninergic Psychedelic 2,5-Dimethoxy-4-Iodoamphetamine on Hippocampal Plasticity and Metaplasticity.

Psychedelic medicine (New Rochelle, N.Y.) September 1, 2024 Zarmeen Zahid, Ziyad W. Sultan, Bryan M Krause et al. 5 citations

Serotonergic psychedelics and ketamine produce rapid and long-lasting symptomatic relief in multiple psychiatric disorders. Evidence suggests that despite having distinct molecular targets, both drugs may exert therapeutic benefit via their pro-neuroplastic effects. Following treatment with ketamine or serotonergic psychedelics, patients are reported to be more open to behavioral change, which...

Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness.

British Journal of Anaesthesia February 1, 2024 Cameron P Casey, Sean Tanabe, Zahra Z Farahbakhsh et al.

Understanding the neural correlates of consciousness has important ramifications for the theoretical understanding of consciousness and for clinical anaesthesia. A major limitation of prior studies is the use of responsiveness as an index of consciousness. We identified a collection of measures derived from unresponsive subjects and more specifically their association with consciousness (any...