Background Late-life depression with inadequate antidepressant response is a pressing clinical issue with limited proven therapies. Nitrous oxide (N 2 O) may offer a new therapeutic avenue with rapid and safe antidepressant effects in late-life depression with inadequate antidepressant response. Methods We conducted a double-blind, randomised, placebo-controlled, single-dose trial (November...
Abstract Mindfulness training (MT) and progressive muscle relaxation (PMR) are widely used stress-reduction practices, yet their neurochemical specificity remains almost unexplored. In a randomized, pre–post study, 30 healthy right-handed female speech-language therapy students were assigned to six weeks of MT or PMR. Short-echo time single-voxel H 1 -MRS (3T PRESS, TE ≈ 35 ms) and structural...
Nitrous oxide (N2O) has recently emerged as a potential fast-acting antidepressant but the cerebral mechanisms involved in this effect remain speculative. We hypothesized that the antidepressant response to an Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) would be associated with changes in cerebral connectivity and brain tissue pulsations (BTP). Thirty participants (20 with a major...