Background Late-life depression with inadequate antidepressant response is a pressing clinical issue with limited proven therapies. Nitrous oxide (N 2 O) may offer a new therapeutic avenue with rapid and safe antidepressant effects in late-life depression with inadequate antidepressant response. Methods We conducted a double-blind, randomised, placebo-controlled, single-dose trial (November...
Nitrous oxide (N2O – also known as Hilarious Gas) has recently emerged has a potential fast-acting antidepressant, based on a number of randomized controlled trials (RCT) in young adults with treatment resistant depression (TRD). The antidepressant mechanisms of N2O are not fully understood but may include an antagonist action on NDMA receptors, similar to ketamine. N2O shows additional...
Nitrous oxide (N2O) has recently emerged as a potential fast-acting antidepressant but the cerebral mechanisms involved in this effect remain speculative. We hypothesized that the antidepressant response to an Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) would be associated with changes in cerebral connectivity and brain tissue pulsations (BTP). Thirty participants (20 with a major...