Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: surface expression of CaMKII and NMDA receptor subunits.
Pharmacology, Biochemistry, and Behavior September 9, 2005 S. Moyano, J. Del Río, D. Frechilla 29 citations
Acute 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") treatment induces learning deficits in different animal models. In a passive avoidance learning task in rats, previous studies suggested a role for Ca2+/calmodulin-dependent protein kinase II (CaMKII) and N-methyl-D-aspartate (NMDA) receptors in the acute learning impairment. As cognitive deficits by "ecstasy" in humans have been only...
DOI: 10.1016/j.pbb.2005.07.020 (opens in new tab)
Hippocampus
Animals
Rats, wistar
N-methyl-3,4-methylenedioxyamphetamine
+6