Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: surface expression of CaMKII and NMDA receptor subunits.
S. Moyano, J. Del Río, D. Frechilla
Pharmacol Biochem Behav September 9, 2005 DOI: 10.1016/j.pbb.2005.07.020 (opens in new tab) via PubMed
Summary
AI-generated from the abstractMDMA (ecstasy) alters molecular mechanisms involved in memory formation in the rat hippocampus. Both acute and chronic MDMA exposure change the surface expression of CaMKII and NMDA receptor subunits, key proteins for synaptic plasticity and memory. These findings suggest that MDMA disrupts normal memory-related signaling pathways in the brain.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rat hippocampus |
| Intervention | MDMA |
| Citations | 29 |
| Key finding | MDMA alters surface expression of CaMKII and NMDA receptor subunits in the rat hippocampus, indicating disruption of memory-related molecular mechanisms. |
Abstract
Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: surface expression of CaMKII and NMDA receptor subunits.