9 papers in the library · 157 citations · publishing 2005-2026
Br J Pharmacol June 16, 2026 György Bagdy, Dóra Pothorszki, Noémi Papp et al.
Variability in the effects of ketamine enantiomers across animal models of depression and implications for human studies.
British Journal of Pharmacology June 1, 2026 Szabolcs Koncz, Dóra Pothorszki, Noémi Papp et al. 2 citations
Ketamine consists of two enantiomers, (R)-ketamine and (S)-ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)-enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)-ketamine. The quantitative electroencephalography (qEEG) gamma-enhancing effect of...
Pharmaceuticals (Basel, Switzerland) February 1, 2024 Dóra Pothorszki, Szabolcs Koncz, Dóra Török et al. 7 citations
Differences in the pharmacological effects of (S)-ketamine and (R)-ketamine are at the focus of research. Clinical data and our rat studies confirmed the antidepressant effect of (S)- but not (R)-ketamine, with similar differences in quantitative electroencephalogram (EEG) and sleep effects. In contrast, studies mainly on mice showed some stronger, preferable effects of (R)-ketamine. EEG theta...
International Journal of Neuropsychopharmacology September 25, 2023 Szabolcs Koncz, Noémi Papp, Dóra Pothorszki et al. 29 citations
Abstract Background Racemic ketamine consists of two enantiomers, namely (R)-ketamine and (S)-ketamine, with distinguishable pharmacological properties. Both enantiomers have been reported to show rapid antidepressant effects in rodents. Currently, the (S)-enantiomer has been approved for the treatment of major depression, whereas (R)-ketamine failed to show antidepressant effect in recent...
The Journal of Comparative Neurology March 31, 2011 Csaba Ádori, Rómeó D. Andó, Mária Szekeres et al. 21 citations
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is a popular party drug known to cause selective serotonergic damage. Here we examined the long-term recovery and aging of serotonergic fibers and levels of brain-derived neurotrophic factor (BDNF) after intermittent MDMA administration (15 mg kg(-1) i.p. every 7th day for 4 weeks, MDMA ×4) and a single-dose treatment (15 mg kg(-1) i.p., MDMA...
Psychopharmacology February 2011 Csaba Ádori, Péter Low, Rómeó D Andó et al.
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used recreational drug known to cause selective long-term serotonergic damage. The aim of this study was to characterize the ultrastructure of serotonergic pericarya and proximal neurites in the dorsal raphe nucleus as well as the ultrastructure of serotonergic axons in the frontal cortex of adolescent Dark Agouti rats 3 days after...
European Journal of Neuroscience July 1, 2006 Linda Ferrington, Eszter Kirilly, Douglas E. Mcbean et al. 21 citations
Abstract Acutely, 3,4,‐methylenedioxymethamphetamine (MDMA) induces cerebrovascular dysfunction [ Quate et al ., (2004) Psychopharmacol. , 173 , 287–295]. In the longer term the same single dose results in depletion of 5‐hydroxytrptamine (5‐HT) nerve terminals. In this study we examined the cerebrovascular consequences of this persistent neurodegeneration, and the acute effects of subsequent...
The Journal of Comparative Neurology 2006 Csaba Ádori, Rómeó D. Andó, Gábor G. Kovács et al. 51 citations
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") causes long-term disturbance of the serotonergic system. We examined the temporal, spatial, and cellular distribution of three molecular chaperones, Hsp27, Hsp72, and Hsp90, 3 and 7 days after treatment with 7.5, 15, and 30 mg/kg single intraperitoneal (i.p.) doses of MDMA in Dark Agouti rat brains. Furthermore, we compared the immunostaining...
The International Journal of Neuropsychopharmacology August 1, 2005 Eszter Kirilly, Anita Benkő, Linda Ferrington et al. 26 citations
MDMA causes selective depletion of serotonergic terminals in experimental animals and the consequent decrease in synaptic 5-HT may, inter alia, increase impulsivity. To study the effects of MDMA upon brain function, the behaviour of male Dark Agouti rats exposed to MDMA (15 mg/kg i.p.), two 5-HT1B agonists (CGS-12066A and CP-94,253, both 5 mg/kg i.p.) or saline were investigated in the...