Indian Internet Journal of Forensic Medicine and Toxicology
October 30, 2024
Aravind Ajid, Boban Babu, Abhijith G Jayachandran
Salvia divinorum is a psychoactive plant that produces intense hallucinations and is used as a recreational drug increasingly. The Mazatec Indians used it in spiritual healing sessions. The fact that the drug is easily available through the internet and the lack of restrictions on its use in many countries have contributed to its widespread abuse. There have also been reports of drugs being...
BMC plant biology
October 1, 2024
Scott A. Ford, Rob W. Ness, Moonhyuk Kwon et al.
9 citations
Diviner's sage (Salvia divinorum; Lamiaceae) is the source of the powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of the human Κ-opioid receptor with potential medical applications in the treatment of chronic pain, addiction, and post-traumatic stress disorder. Only two steps of the approximately twelve step biosynthetic sequence leading to SalA have been...
ChemCatChem
August 26, 2024
Soufian Tibouti, Louis Barriault
AbstractSalvinorin A is a powerful hallucinogen in humans, and a selective, high efficacy agonist of the kappa‐opioid receptor (κ‐OR). Salvinorin A is the first plant‐derived ligand with high selectivity for κ‐OR over other receptors, its structure is unrelated to any known opioid receptor ligands, even lacking any nitrogenous moieties. Mechanistically and pharmacologically, salvinorin A is...
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
August 14, 2024
Frederick A. Bagdasarian, Hanne D. Hansen, Chi‐hyeon Yoo et al.
This work utilized fMRI to assess the influence of the psychedelics, Psilocybin, a serotonergic agonist, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on functional connectivity (FC) in non-human primates. We used a seed-based FC analysis, probing regions of interest associated with psychedelic hallucinogens. Our findings highlight the overlapping and differing influence of these...
ACS Chemical Neuroscience
June 25, 2024
Jingyuan Chen, Frederick A. Bagdasarian, Hanne D. Hansen et al.
11 citations
The extent of changes in functional connectivity (FC) within functional networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, a classical serotonergic psychedelic, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on resting-state FC in nonhuman primates. We highlight overlapping and...
Scientific Reports
March 24, 2024
Maciej Jakobina, Jacek Łyczko, Antoni Szumny et al.
Abstract Coleus scutellarioides (L.) Benth. is a popular species in the world, known for its characteristic magnificent colourful leaves. The study has revealed that the contents of rosmarinic acid and caffeic acid are significantly higher in the plant tissues cultivated in vivo than when under in vitro conditions. The performed qualitative and quantitative analyses confirmed the presence...
Physiologia plantarum
2024
Iris Ngo, Rahul Kumar, Liang Li et al.
6 citations
Salvia divinorum is a hallucinogenic plant native to the Oaxaca in Mexico. The active ingredient for psychotropic effects in this plant is salvinorin A, a potent and highly selective κ-opioid receptor agonist. Salvinorin A is distinct from other well-known opioids, such as morphine and codeine, in that it is a non-nitrogenous diterpenoid with no affinity for μ-opioid receptor, the prime...
Synfacts
September 14, 2023
Dirk Trauner, Tongil Ko
Key words Salvinorin - Reformatsky reaction - Robinson annulation - Hayashi conjugate addition Publication History Article published online: 14 September 2023 © 2023. Thieme. All rights reserved Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
Apple Academic Press eBooks
September 5, 2023
Chinnadurai Immanuel Selvaraj, Vrushali Manoj Hadkar, Gadwal Shaik Nishat Anjum
Salvia divinorum , or the ‘diviner’s sage’, is a member of the Lamiaceae family. it is a perennial shrub-like herb and grows to a height of 0.5–1.5 metres. S. divinorum is native to the Sierra Mazateca in Oaxaca, Mexico where the Mazatec people consume the plant&s;s fresh leaves or leaf preparations for medicinal, therapeutic, and divinatory rites. The plant is a rich source of diterpenes and...
Chemistry - A European Journal
September 1, 2023
Huy Tran, Philippe McGee, Louis Barriault
The formal synthesis of (±)-salvinorin A is presented. Our approach utilizes two distinct gold(I) catalytic processes. The combination of a gold(I)-catalyzed reaction with an intermolecular Diels-Alder reaction followed by a gold(I)-catalyzed photoredox reaction generated in eight steps the framework of the natural product with high diastereoselectivity.