An Overview of Syntheses of Salvinorin A and its Analogues
ChemCatChem August 26, 2024 Soufian Tibouti, Louis Barriault
AbstractSalvinorin A is a powerful hallucinogen in humans, and a selective, high efficacy agonist of the kappa‐opioid receptor (κ‐OR). Salvinorin A is the first plant‐derived ligand with high selectivity for κ‐OR over other receptors, its structure is unrelated to any known opioid receptor ligands, even lacking any nitrogenous moieties. Mechanistically and pharmacologically, salvinorin A is...