Mounting evidence suggests safety and efficacy of psychedelic compounds as potential novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug Administration in a new class of antidepressants, and 3,4-methylenedioxymethamphetamine (MDMA) is undergoing phase III clinical trials for post-traumatic stress disorder. Psilocybin and lysergic acid diethylamide (LSD) are being...
December 1, 2020Caroline Mathon, Christèle Widmer, R. Mégevand et al.
Objectif Depuis de nombreuses annees, la politique en matiere de drogues est basee en Suisse sur quatre piliers, a savoir la prevention, la therapie, la repression et la reduction des risques. Parmi les actions mises en œuvre concernant la reduction des risques lies aux consommations recreatives de substances psychoactives, une nouvelle offre a ete proposee depuis 2019 a Geneve, consistant en...
ABSTRACT Over the last three decades, the renaissance of interdisciplinary research into psychedelic drugs has challenged the Cartesian notions of subjectivity and identity that have endured throughout modernity. But as work in this field reaches new degrees of complexity, the limitations of verbal and textual language are presenting barriers to conventional forms of scholarship. Across the...
In their recent article entitled “Psychedelic Psychiatry's Brave New World,” Nutt et al. (1) wrote that new research on psychedelic drugs, especially psilocybin, has highlighted their potential for psychiatric disorder management. In the past decade, many studies focused on psilocybin effects on mood disorders (2) showing that it can significantly improve depressive symptomatology for weeks and...
Mahler, who had mobilized the youth of his day against slovenly Tradition, reerupted into a newly youthful popular culture in the 1960s thanks to both the centenary of his birth and the advent of the long-playing record. Not only musicians were touched by the wave of new recordings; modern pop culture and youthful “avant-garde” now blithely bridged the once-opposed realms of “high” and “low”...
BACKGROUND: The glutamatergic modulator ketamine has created a blueprint for studying novel pharmaceuticals in the field. Recent studies suggest that "classic" serotonergic psychedelics (SPs) may also have antidepressant efficacy. Both ketamine and SPs appear to produce rapid, sustained antidepressant effects after a transient psychoactive period. METHODS: This review summarizes areas of...
Despite a politically vilified past, classical psychedelics, including lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT), are experiencing a revival in scientific and clinical research. When used under the appropriate guidance and setting, these substances show promise for substantially improving well-being and reducing mental ill-health alongside an excellent safety...
This chapter stresses how illicit drugs were difficult to obtain in America and were often heavily diluted by the early 1940s. It illustrates the conditions that limited the supply of drugs in the Unites States, such as the massive diversion of resources toward a single national effort, the militarization of almost every major sea passage, an extremely limited supply of private aircraft and...
The aim of this work was to investigate the applicability of a mathematical model developed for the description of supercritical fluid extraction (SFE) of cannabinoids from marijuana and hashish for liquid extraction of other substances. The mentioned model is applicable for dynamic SFE whose implementation is analogous to liquid-solid extraction in quasi-counter current mode. According to this...
Abstract The microdosing of mind-altering substances, like LSD and magic mushrooms, is a trend among young creatives, who report enhanced creativity, improved focus, and other productivity-enhancing effects. This chapter, Chemical Creativity , describes how both users and researchers have been exploring the range of effects of microdosing, including through more experimental ethnographic...