Clinical and Translational Science
April 18, 2017
T. Burt, Robert J. Noveck, D. MacLeod et al.
The safe and efficient translation of biological insights into human applications is a major public health challenge. Safety concerns are associated with substantial preclinical developmental costs, delaying entry into first-in-human testing. We introduce a novel drug development tool, Intra-Target Microdosing (ITM), combining features of “microdosing,” the systemic subpharmacological testing...
Clinical Pharmacokinetics
February 2, 2017
M. Mooij, Esther van Duijn, C. Knibbe et al.
BackgroundWe previously showed the practical and ethical feasibility of using [14C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, using [14C]paracetamol (AAP).MethodsInfants admitted to the intensive care unit received a single oral...
US Ophthalmic Review
2017
Sepehr Bahadorani, Michael A Singer
The treatment of diabetic macular edema (DME) has become one of the most challenging management issues faced by ophthalmologists in daily practice. This is partly due to the multifactorial nature of DME, progression of the disease and the clinical capacity needed to administer intravitreal injections. In recent years, the treatment options for DME have expanded to include intravitreal...
Chemical Research in Toxicology
November 21, 2016
Tiffany M. Scharadin, Hongyong Zhang, Maike Zimmermann et al.
Gemcitabine metabolites cause the termination of DNA replication and induction of apoptosis. We determined whether subtherapeutic "microdoses" of gemcitabine are incorporated into DNA at levels that correlate to drug cytotoxicity. A pair of nearly isogenic bladder cancer cell lines differing in resistance to several chemotherapy drugs were treated with various concentrations of 14C-labeled...
Experimental Agriculture
October 1, 2016
ALI Ibrahim, Robert Clement Abaidoo, Dougbedji Fatondji et al.
SUMMARY: Recent studies have reported the benefits of fertilizer microdosing in increasing crop yields in low input cropping systems. Little information is however available on the mechanisms underlying this effect. The objective of this study was therefore to explore the root-based mechanisms governing the growth enhancing phenomena of the fertilizer microdosing technology. A two-year...
Experimental Agriculture
July 1, 2016
Getachew Sime, Jens B. Aune
SUMMARY: Intensification of maize production is imperative to improve food security for the rising population in the central rift valley (CRV) of Ethiopia, whose livelihood is principally based on rainfed maize that operates under shrinking landholding and high seasonal rainfall variability. This study examined different levels of intensification options in maize production by sequentially...
Sustainable Agriculture Research
May 3, 2016
David Natcher, Erika Bachmann, Jeremy Pittman et al.
Soil degradation and low crop productivity negatively affect the food security of smallholder farmers in West Africa. Various agricultural techniques have been developed as components of food security interventions, but their effectiveness in addressing food insecurity in part depends upon farmers’ abilities to adopt these techniques. In this paper we present the results of a social network...
Sustainable Agriculture Research
May 3, 2016
Erika Bachmann, David Natcher, Suren Kulshreshtha et al.
Various agricultural techniques have been developed as components of food security interventions, but their effectiveness in addressing food insecurity in part depends upon the effectiveness of these techniques in fulfilling farmers’ objectives. This paper presents the results of research that examined the constraints that limit the adoption of microdosing by farmers in northwest Benin. The...
April 15, 2016
D. Sogodogo, Béjamé Coulibaly, B. Coulibaly et al.
1 Agronome système à l’Institut d’Economie Rurale, Coordinateur national du projet 2009 SHP 003 AGRA Microdose au Mali, Chef de l’Equipe Système de Production et de Gestion des Ressources Naturelles, Station de Recherche Agronomique de Cinzana, Mali BP 214 Segou 2 Agronome Gestion Intégrée de la Fertilité des Sols, Chercheur dans l’Equipe Système de, Production et de Gestion des Ressources...
Clinical and Translational Science
February 26, 2016
Tal Burt, K Yoshida, Graham Lappin et al.
91 citations
A number of drivers and developments suggest that microdosing and other phase 0 applications will experience increased utilization in the near-to-medium future. Increasing costs of drug development and ethical concerns about the risks of exposing humans and animals to novel chemical entities are important drivers in favor of these approaches, and can be expected only to increase in their...