Introduction: Ketamine is an evidenced-based treatment for depression, and it has shown promise in addressing many other mental health conditions related to work-related stress or burnout, such as anxiety and post-traumatic stress disorder. Ketamine-assisted psychotherapy (KAP) is part of an emerging model of psychedelic medicine that employs psychoactive agents to support the psychotherapeutic...
Archives of ToxicologyApril 19, 2025António B Pimpão, Luísa Teixeira-Santos, Nuno R Coelho et al.
We were pioneers in describing aryl hydrocarbon receptor (AhR) activation by chronic intermittent hypoxia (CIH) in a rat pre-clinical model. This model mimics hypertension (HTN) secondary to obstructive sleep apnea, enabling longitudinal investigation of hypertension development. Concerns about the influence of barbiturates on AhR-regulated enzymes led us to opt for ketamine/medetomidine...
Subanesthetic ketamine is currently used as a rapid-acting treatment for varied neuropsychiatric disorders. However, the mechanistic underpinnings of its therapeutic action remain unclear, and emerging clinical and preclinical evidence highlights a potential involvement of the opioid system. We used pharmacological functional ultrasound imaging data acquired during and after ketamine...
TrialsApril 17, 2025Arash Mansoori, Amir Bazrafshan, Jamshid Ahmadi et al.4 citations
The concomitant presence of major depressive disorder (MDD) and opioid use disorder (OUD) poses a formidable clinical challenge, warranting effective interventions that address both psychiatric and addictive components. This study sought to compare the efficacy of adjunctive ketamine and buprenorphine in mitigating anxiety symptom severity and craving intensity in individuals with co-occurring...
Objective: Psychedelics are able to trigger highly intense and profound alterations in self-consciousness, perception, affective, and cognitive processes. Indeed, recent studies show that ketamine and psilocybin could be used as fast-acting antidepressants. However, the molecular and neurochemical mechanisms of these psychedelics and their actions at the level of diverse brain structures...
Childhood trauma is a well‐established risk factor for major depressive disorder (MDD) and is often associated with attenuated response to conventional antidepressant therapies. Ketamine has emerged as an effective treatment for treatment‐resistant depression (TRD), but the impact of childhood trauma on its effectiveness remains unclear. Herein, we aimed to determine whether childhood trauma...
JBI evidence synthesisApril 16, 2025Laura Borges Lopes Garcia Leal, Jadson Nilo Pereira Santos, Valquíria Aparecida da Silva et al.
This scoping review will map the available evidence on nursing care provided to adults receiving ketamine infusion for pain management in hospitals and outpatient clinics. The use of intravenous ketamine infusions has increased in various contexts, particularly for pain management as part of a multimodal approach. Although ketamine is associated with a lower risk of hemodynamic disorders and...
Ketamine is known for its rapid antidepressant effect, but its impact on affective information processing (including attentional bias [AB], a putative cognitive mechanism of depression) remains largely unexplored. We leveraged a novel measurement of AB and sought to 1) establish adequate test-retest reliability and validity among participants with depression prior to ketamine treatment and 2)...
The Journal of ECTApril 15, 2025Erich J Conrad, Zachary F Stielper, Isabelle V Mermilliod et al.
The presence of catatonia refractory to routine pharmacologic management is often subsequently managed by electroconvulsive therapy. However, legal obstacles that delay the initiation of electroconvulsive therapy in a timely fashion may be present. This may lead to prolonged risks associated with immobility and result in other procedures such as percutaneous endoscopic gastrostomy (PEG) tube...
Ketamine has emerged as a rapid-acting and robust antidepressant1,2. However, the mechanism of its antidepressant action remains enigmatic. The core issue that has yet to be resolved is whether NMDA receptors (NMDARs), which are subject to open channel blockade by ketamine3,4, mediate the antidepressant effect. NMDARs naturally undergo alternative splicing of the obligatory GluN1 subunit5,...