The International Journal of Neuropsychopharmacology
April 17, 2023
Shokouh Arjmand, Marie Vadstrup Pedersen, N. Silva et al.
Abstract Background Recent preclinical and clinical studies have shed light on the possible impact of sex and estrous/menstrual cycle on ketamine’s antidepressant action but with incongruous results. The preclinical studies that have shown the effects of ovarian sex hormones have not done so in animal models of depression. Thus, the aim of the present study is to scrutinize the acute behavioral...
bioRxiv Preprint Server
April 12, 2023
Malika S. Datta, Yannan Chen, Shradha Chauhan et al.
6 citations
preprint
Ketamine is a multifunctional drug with clinical applications as an anesthetic, as a pain management medication and as a transformative fast-acting antidepressant. It is also abused as a recreational drug due to its dissociative property. Recent studies in rodents are revealing the neuronal mechanisms that mediate the complex actions of ketamine, however, its long-term impact due to prolonged...
Advanced Healthcare Materials
April 8, 2023
Jing Ge, Ronghua Tan, Qian Gao et al.
Ketamine (KA), commonly used as an anesthetic, is now widely studied as an antidepressant for the treatment of depression. However, due to its side effects, such as addiction and cognitive impairment, the dosage and frequency of (S)‐ketamine approved by the FDA for the treatment of refractory depression is very low, which limits its efficacy. Here, a new multifunctional nanocarrier system...
International Journal of Health Sciences
April 5, 2023
Luísa Soares Capa, Gabrielle Simon Tronco, Virginia Nascimento Reinert et al.
: Treatment-resistant depression is a common psychiatric disorder that can lead to significant disability and decreased quality of life for patients. In recent years, there has been growing interest in the combination of intravenous ketamine and electroconvulsive therapy (ECT) for the treatment of treatment-resistant depression. Ketamine is an anesthetic that is an N-methyl-D-aspartate (NMDA)...
The Journal of Clinical Psychiatry
April 5, 2023
Albert Yeung, Guy Sapirstein, Laura D Crain et al.
Although consensus in the field is lacking, the most common definition for treatment-resistant depression (TRD) requires a minimum of 2 prior treatment failures with confirmed adequate dose and duration. This article presents a clinical example of TRD in a patient with a long history of depression and inadequate response to treatment. The prominent feature is the patient's persistent...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
April 4, 2023
C. C. M. D. Menezes da Silveira, Sabrina de Carvalho Cartágenes, Natália Harumi Correa Kobayashi et al.
Drug abuse is a global public health problem among adolescents, with alcohol often used in association with other psychotropic drugs, such as ketamine. Considering the scarcity of evidence, this study aimed to investigate emotional behavioral effects induced by ethanol plus ketamine co-abuse, as well as oxidative biochemistry, and neurotrophic mediator in the prefrontal cortex and hippocampus...
Brain Research
April 1, 2023
Sakineh Alijanpour, Ameneh Rezayof
Considering the increasing usage of ketamine as a recreational drug with hallucinogenic properties and also scarce studies about receptor systems responsible for its effects, in the present study we aimed to investigate whether the activation of the ventral hippocampal (VH) CB1 cannabinoid receptors affects the anxiety-like behaviors induced by ketamine. Also, the levels of BDNF and c-Fos...
Australasian Psychiatry
April 2023
William Lugg
To review the sequence of events that led to the Therapeutic Goods Administration (TGA) approval of esketamine in Australia, and to explore the potential ethical and clinical consequences of it. Trust in the TGA is of paramount importance to Australian psychiatrists. The approval of esketamine raises serious questions about the processes, independence and authority of the TGA, and therefore the...
Advanced Biomedical Research
April 1, 2023
Afsaneh Karbasi Amel, Farzaneh Hosseini
5 citations
Background: Children suffer from a high prevalence of anxiety problems that require prompt treatment. It has been demonstrated that ketamine offers rapid anti-anxiety effects. This study aimed to evaluate ketamine's anti-anxiety impact in the treatment of children with school-refusal separation anxiety disorder. Materials and Methods: In this open-labeled randomized clinical trial, 71 children...
Experimental and Clinical Psychopharmacology
April 1, 2023
Brett Melanson, Michael Wolter, Zion Leatham et al.
This study was designed to explore the clinical belief that "set and setting" play an important role in favorable responses to psychedelic agents such as ketamine (KET). In fact, there is evidence in animals that the antidepressant effect of this drug may involve drug-environment interactions in which a context paired with its effects acquires the ability to influence behavior. Therefore, it...