Muyan Zuo, Yaozu Li, John P Williams et al.
preprint
Purpose: Depression combined with insomnia is a complex bidirectional relationship that is more difficult to treat versus a single disorder, and there is a lack of effective treatments available. In this study, we carried out a novel way to simultaneously intervene in depression combined with insomnia and examined functional magnetic resonance imaging (fMRI) to help further elucidate the...
Shurong Li, Zhifang Zhuo, Renwei Li et al.
preprint
Abstract Background Postpartum depression (PPD) after cesarean delivery is a common complication. Esketamine's effects on PPD in women undergoing cesarean section remain contradictory, despite ketamine's prophylactic effects. This study evaluated the effect of esketamine as an adjunct to patient-controlled intravenous analgesia (PCIA) to prevent PPD in women undergoing caesarean section....
Hannah Tramontano, Jeffrey Fetter, Mohamed Wagdy ElSayed
preprint
Background: Borderline Personality Disorder (BPD) affects 1.35% of the population and is frequently comorbid with Major Depressive Disorder (MDD), which is frequently treatment-resistant (TRD). Patients with comorbid illness have worse treatment outcomes and functional impairment. Esketamine could ameliorate symptoms of both illnesses. Methods: We conducted a retrospective chart review of...
Zeynep Yoldas, Willys Cantenys, Morgane Tronche et al.
preprint
Background: Facial emotion recognition deficits are well defined in depression but understudied in treatment-resistant depression (TRD). Over the past decades, subanesthetic doses of ketamine have emerged as an effective treatment for TRD, but its effect on affective processing is still little known. Approaches from computational psychiatry, such as sequential evidence sampling models of...
Amanda Timek, Catherine Daniels-Brady, Stephen Ferrando
preprint
Abstract Background : Anorexia nervosa is a life-threatening psychiatric illness with a high mortality rate and limited treatment options. This illness is frequently comorbid with major depressive disorder, leading to additional obstaces in patient quality of life, and increasing the mortality rate further due to risk of suicide. Ketamine, an competitive N-methyl-D-aspartate receptor...
Research Square
Jack Swain, Davis Carter, Leonardo Vando et al.
preprint
Abstract Background Sleep disturbances are a significant public health burden affecting 50 to 70 million adults in the United States and contributing to impaired cognition, accelerated disease progression, and increased mortality risk. 1,2 Available pharmacological treatments carry notable safety and tolerability risks, while access to the leading evidence-based behavioral intervention,...
Research Square
Norihiro Okada, Kenshiro Oshima, Akiko Maruko et al.
preprint
Abstract In response to a state of stress, the body attempts to maintain protein homeostasis through intron retention (IR). In other words, by examining which genes undergo IR under stress (i.e., IR genes), it is possible to analyze what type of stress the body is experiencing (Okada et al. 2024 Front.Psychiatry). Using this principle, we re-analyzed the RNA-seq data of non-responders and...
Research Square
Adam Włodarczyk, Wiesław Jerzy Cubała, Maria Węgielnik-gałuszko et al.
preprint
Abstract Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with Major...
Hugo Bottemanne, Orphée Morlaàs, Anne Claret et al.
4 citations
preprint
Treatment resistant depression (TRD) is a tremendous health problem that has encouraged novel treatment strategies involving sub-anesthetic ketamine infusions. While ketamine induces rapid and sustained clinical improvement, its cognitive effects are less well known. Here we tested if ketamine alters the negative expectancies about the future that are insensitive to disconfirming information,...
Adam Włodarczyk, Wiesław Jerzy Cubała, Maria Węgielnik-gałuszko et al.
1 citation
preprint
Abstract Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the safety of intravenous ketamine treatment concerning dissociative and psychotic measures in TRD inpatients with Major Depressive Disorder (MDD) and...