Frontiers in Immunology2025David Qixiang Chen, José Adalberto Inzunza Domínguez, Juan Manuel Valle Uzeta et al.3 citations
Multiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by demyelination and neuronal loss. Traditional therapies often fail to halt disease progression or reverse neurological deficits. Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients...
Abstract: This article aims to present "iboga," also known as "sacred wood," as an endogenous knowledge used traditionally in the spiritual and medicinal rituals of the people of Gabon during initiation ceremonies such as bwiti, mumbwiri, and many other rites. This plant, considered a natural, cultural, and national heritage, allows for transcendence between physical and invisible worlds...
The iboga alkaloids are a family of monoterpene indole alkaloids first discovered from the root of Tabernanthe iboga. The major alkaloid constituent in the root, ibogaine, has garnered interest for its anti-addictive properties. Ibogaine has been shown to reduce opiate, amphetamine, alcohol, and nicotine self-administration in rodents. However, ibogaine itself is less than optimal as a...
Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and a highly complex molecular mechanism. We introduce a class of iboga alkaloids - termed oxa-iboga - defined as benzofuran-containing iboga analogs and...
Ibogaine is a potent atypical psychedelic that has gained considerable attention due to its antiaddictive and antidepressant properties in preclinical and clinical studies. Previous research from our group showed that ibogaine suppresses sleep and produces an altered wakefulness state, which resembles natural REM sleep. However, after systemic administration, ibogaine is rapidly metabolized to...
The aim of this study was to determine the anti-hypersensitivity activity of novel non-hallucinogenic compounds derived from iboga alkaloids (i.e., ibogalogs), including tabernanthalog (TBG), ibogainalog (IBG), and ibogaminalog (DM506), using mouse models of neuropathic (Chronic Constriction Injury; CCI) and visceral pain (dextrane sulfate sodium; DSS). Ibogalogs decreased mechanical...
Ibogaine is an organic indole alkaloid that is used in alternative medicine to combat addiction. Numerous cases of life-threatening complications and sudden deaths associated with ibogaine use have been reported, and it has been hypothesized that the adverse effects are related to ibogaine's tendency to induce cardiac arrhythmias. Considering that the bioavailability of ibogaine and its primary...
This article aims to present "iboga," also known as "sacred wood," as an endogenous knowledge used traditionally in the spiritual and medicinal rituals of the people of Gabon during initiation ceremonies such as bwiti, mumbwiri, and many other rites. This plant, considered a natural, cultural, and national heritage, allows for transcendence between physical and invisible worlds through its...
... I immediately recognized The Ibogaine Effect...” —Hunter S. Thompson, Fear and Loathing: On the Campaign Trail ‘72 Reading Hunter S. Thompson's dispatches from the 1972 Democratic primary race in Rolling Stone was the first time I learned about a mysterious drug called ibogaine. I never believed that Edmund Muskie was taking a psychedelic substance on the hustings. Mr. Thompson later...
CureusJune 1, 2024David Mestre, Alexandra Paula, Francisco P Gil et al.
Opioid dependence is a common problem, and therapeutic alternatives are scarce and ineffective. Ibogaine, illegal in several countries, has been reported as a possible therapy in alternative clinics and it is also used as a recreational drug, despite its cardiotoxic potential, including QT prolongation. We report a case of long QT leading to multiple episodes of cardiac arrest after a single...