This study aimed to validate and culturally adapt the Altered States of Consciousness Rating Scale (OAV) and Five Dimensional-Altered States of Consciousness Questionnaire (5D-ASC) for Brazilian Portuguese to measure altered states of consciousness in the context of psychedelic research. A parallel back-translation model was employed with expert reviews to ensure linguistic and cultural...
Brain ResearchJune 19, 2025Zoé Dary, Paul Kobliska, Jacques Léonard et al.
The vestibular system plays a crucial role in body and self perception, as evidenced by the effects of artificial vestibular stimulation in healthy individuals and the depersonalization-like symptoms observed in patients with otoneurological disorders. However, its role in the bodily self-an immediate and pre-reflective form of self-consciousness-remains relatively unexplored. This study...
Recent studies intensively explore psilocybin's antidepressant potential, but variables like previous experience, repeated use, setting, and sex remain underexplored. This study examines acute and long-term effects of psilocybin in healthy individuals. A double-blind, placebo-controlled, cross-over study included 40 healthy participants (20 females, mean age 38). Each received two doses of...
Dissociative experiences are prevalent in young people, where they are associated with greater clinical severity of co-occurring difficulties and increased risk of self-harm and suicide. Recent research suggests transdiagnostic dissociation plays a role in the development and maintenance of mental health problems such as anxiety, depression and psychosis, and may therefore constitute a novel...
Treatment-resistant depression (TRD) remains a challenge, with many patients unresponsive to standard antidepressants. NN-dimethyltryptamine (DMT), a fast-acting psychedelic, offers potential benefits due to its rapid onset and short duration. This review, registered with the Open Science Framework (DOI: 10.17605/OSF.IO/6D9WC), summarizes the safety and tolerability of DMT in early-phase...
Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carry personal meaning. While research has demonstrated the capacity for these compounds to promote psychological wellbeing, it has yet to be shown to what extent they modulate "meaning in life", a specific contributor to mental and physical health....
Haunted People Syndrome (HP-S) characterizes recurrent ‘ghostly episodes’ as an interactionist phenomenon emerging from people with heightened somatic-sensory sensitivities that are stirred by dis-ease states, contextualized with paranormal belief, and reinforced via perceptual contagion and threat-agency detection. We tested the applicability of this psychological model via a three-part,...
The distinction between dissociative disorders (DDs) and schizophrenia spectrum disorders (SSDs) in different categories since DSM-III presumes a clear-cut distinction between both disorders. However, empirical studies did not reveal a clear distinction between the disorders on a symptom level. The aim of the current study was to further examine the overlap and differences in symptoms between...
Lysergic acid diethylamide (LSD) is currently being investigated as a potential treatment for psychiatric and neurological disorders. Different LSD formulations (base or tartrate, oral or intravenous) are being used. Unclear is whether LSD base and tartrate pharmacokinetics are equivalent. Additionally, LSD's absolute oral bioavailability is unknown. Therefore, we tested the bioequivalence of...
Chanting is a universal practice with deep ethnocultural roots. More recently, chanting has become popular on online platforms and meditation apps which have extended chanting practices beyond their original cultural, sacred, and healing traditions. The aim of the current study was to determine if online chanting meditation promotes altered states of consciousness and psychosocial benefits when...