Psychiatry Research
May 30, 2009
Michael Schredl, Mathias Berger, Dieter Riemann
Trimipramine is a sedating tricyclic antidepressant which is not only effective in the treatment of depression but also in primary insomnia. In contrast to most other antidepressants, trimipramine does not affect rapid eye movement sleep. In a large sample of depressive outpatients (N = 3926), the effect of trimipramine on dream recall and dream emotions was studied. The effect of trimipramine...
Toxicology and Applied Pharmacology
May 15, 2009
Jung Woo Eun, Seung Jun Kwack, Ji Heon Noh et al.
The amphetamine derivative (+/-)-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliative emotional response. MDMA is a potent monoaminergic neurotoxin with the potential to damage brain serotonin and/or dopamine neurons. As the majority of MDMA users are young adults, the risk that users may expose the fetus...
Pharmacology & Therapeutics
May 3, 2009
Rodrigo Machado‐Vieira, Giacomo Salvadore, Nancy Diazgranados et al.
Existing treatments for major depressive disorder (MDD) usually take weeks to months to achieve their antidepressant effects, and a significant number of patients do not have adequate improvement even after months of treatment. In addition, increased risk of suicide attempts is a major public health concern during the first month of standard antidepressant therapy. Thus, improved therapeutics...
The Journal for Nurse Practitioners
May 1, 2009
Mary S. Koithan
Mind-body therapies are among the most widely recommended and used form of complementary and alternative medicine. Nursing has long championed these interventions, citing the healing potential of the mind on physiological systems. Professional beliefs about the inherent holism of the human being are now supported by advances in science; there is basic bench research that now suggests an...
Neurotoxicity Research
May 2009
Tiziana Rubino, Natalia Realini, Daniela Braida et al.
We recently demonstrated that Delta(9)-tetrahydrocannabinol (THC) chronic administration in female adolescent rats induces alterations in the emotional circuit ending in depressive-like behavior in adulthood. Since cognitive dysfunction is a major component of depression, we assessed in these animals at adulthood different forms of memory. Adolescent female rats were treated with THC or its...
Aging & Mental Health
May 2009
Kate Splevins, Alistair M. S. Smith, Jane Simpson
The study aimed (1) to investigate changes in older adults' emotional wellbeing (specifically depression, anxiety and stress levels) and mindful ability following a mindfulness-based cognitive therapy (MBCT) course; (2) to explore correlations between mindfulness (measured as an overall ability and as individual components; observe, describe, act with awareness and accept without judgement) and...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
April 30, 2009
Lêda S B Garcia, Clarissa M Comim, Samira S Valvassori et al.
Several studies have supported the idea that ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) is an important player in the etiology of psychopathologies, such as anxiety disorders and major depression. Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in rodents subjected to animal models of depression. In this context, the present...
Educational Media Reviews Online
April 27, 2009
Fran Mentch
Distributed by National Film Board of Canada, 1123 Broadway, Suite 307, New York, NY 10010; 800-542-2164Produced by Kent MartinDirected by Connie Littlefield2002, DVD, color, 57 min. If you need a film demonstrating that science and medicine are culture bound, this is it. As a member of the baby-boom generation I sat down to watch this film thinking, what can I learn about LSD that I don’t...
Journal of Pain
April 2009
Lance M. McCracken, Edmund Keogh
People often respond with distress and avoidance to their own negative experiences, such as the physical, cognitive, and emotional aspects of depression or anxiety. When people with chronic pain respond this way, their overall level of distress may increase, they may struggle to avoid their emotional experiences, and their daily functioning may decrease. The purpose of this study was to examine...
Behaviour Research and Therapy
March 27, 2009
Mindfulness and reduced cognitive reactivity to sad mood: evidence from a correlational study and a non-randomized waiting list controlled study.